abstract：:Cardiomyocyte death secondary to transient ischaemia occurs mainly during the first minutes of reperfusion in the form of contraction band necrosis. Research on the mechanisms leading to sarcolemmal rupture and necrosis during initial reperfusion identified several promising pharmacological targets directed either to ...

journal_title：Cardiovascular research

authors： Inserte J,Barrabés JA,Hernando V,Garcia-Dorado D

更新日期：2009-07-15 00:00:00

abstract：:The most critical determinant of prognosis in patients with acute myocardial infarction (MI) is infarct magnitude, which can be established within several hours of an attack. The importance of the subsequent healing process is not negligible, however. In fact, much experimental and clinical evidence suggests that late...

journal_title：Cardiovascular research

authors： Takemura G,Nakagawa M,Kanamori H,Minatoguchi S,Fujiwara H

更新日期：2009-07-15 00:00:00

abstract：AIMS:Despite their ability to cause septic shock and myocardial dysfunction, components of Gram-negative bacterial cell walls, like lipopolysaccharide, have been shown in numerous studies to induce myocardial protection during ischaemia-reperfusion injury. Muramyl dipeptide (MDP) is another such component recognized by...

journal_title：Cardiovascular research

authors： Sicard P,Jacquet S,Kobayashi KS,Flavell RA,Marber MS

更新日期：2009-07-15 00:00:00

abstract：AIMS:Both mitochondria and nitric oxide (NO*) contribute to cardioprotection by ischaemic preconditioning (IPC). IPC causes mild uncoupling of mitochondria via uncoupling proteins (UCPs) and the adenine nucleotide translocase (ANT), and mild uncoupling per se is cardioprotective. Although electrophilic lipids are known...

journal_title：Cardiovascular research

authors： Nadtochiy SM,Baker PR,Freeman BA,Brookes PS

更新日期：2009-05-01 00:00:00

abstract：:Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury. Incubation of S1P with cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischaemia or ...

journal_title：Cardiovascular research

authors： Karliner JS

更新日期：2009-05-01 00:00:00

abstract：AIMS:Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investi...

journal_title：Cardiovascular research

authors： Liu SL,Li YH,Shi GY,Tang SH,Jiang SJ,Huang CW,Liu PY,Hong JS,Wu HL

更新日期：2009-04-01 00:00:00

abstract：AIMS:Although the use of drug-eluting stents (DESs) has been shown to limit neointima hyperplasia, currently available DESs may adversely affect re-endothelialization. To evaluate whether a novel gene silencer pyrrole-imidazole (PI) polyamide targeting transforming growth factor (TGF)-beta1 is a candidate agent for the...

journal_title：Cardiovascular research

authors： Yao EH,Fukuda N,Ueno T,Matsuda H,Nagase H,Matsumoto Y,Sugiyama H,Matsumoto K

更新日期：2009-03-01 00:00:00

abstract：AIMS:Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this A...

journal_title：Cardiovascular research

authors： Ding Y,Li YL,Zimmerman MC,Davisson RL,Schultz HD

更新日期：2009-03-01 00:00:00

abstract：AIMS:Moderate wine consumption is associated with a significant reduction of cardiovascular mortality. The molecular basis of this phenomenon remains unknown. Platelet-derived growth factor (PDGF) is an important contributor to atherogenesis. We investigated the effects of selected red and white wines on PDGF receptor ...

journal_title：Cardiovascular research

authors： Sparwel J,Vantler M,Caglayan E,Kappert K,Fries JW,Dietrich H,Böhm M,Erdmann E,Rosenkranz S

更新日期：2009-03-01 00:00:00

abstract：:The failing heart is characterized by alterations in energy metabolism, including mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially compensated by an increase in glucose utilization. Together, these changes lead to an impaired capacity to convert chemical energy into mecha...

journal_title：Cardiovascular research

authors： van Bilsen M,van Nieuwenhoven FA,van der Vusse GJ

更新日期：2009-02-15 00:00:00

abstract：:In acute myocardial infarction (MI), reactive oxygen species (ROS) are generated in the ischaemic myocardium especially after reperfusion. ROS directly injure the cell membrane and cause cell death. However, ROS also stimulate signal transduction to elaborate inflammatory cytokines, e.g. tumour necrosis factor-alpha (...

journal_title：Cardiovascular research

authors： Hori M,Nishida K

更新日期：2009-02-15 00:00:00

abstract：AIMS:Hypercholesterolaemia and myeloperoxidase (MPO) overexpression are two well-recognized risk factors for ischaemic heart disease. Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists have recently been shown to reduce ischaemic heart injury in hypercholesterolaemic animals. However, whether PPARgam...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Qu Y,Lau WB,Lopez BL,Christopher TA,Koch W,Yue TL,Ma XL

更新日期：2009-02-01 00:00:00

abstract：AIMS:Mobilization of stem cells/progenitors is regulated by the interaction between stromal cell-derived factor-1 (SDF-1) and its ligand, CXC chemokine receptor 4 (CXCR4). Statins have been suggested to ameliorate pulmonary arterial hypertension (PAH); however, the mechanisms involved, especially their effects on proge...

journal_title：Cardiovascular research

authors： Satoh K,Fukumoto Y,Nakano M,Sugimura K,Nawata J,Demachi J,Karibe A,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2009-01-01 00:00:00

abstract：AIMS:Adrenomedullin (AM) is a multifunctional peptide hormone that plays a significant role in vasodilation and angiogenesis. Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedem...

journal_title：Cardiovascular research

authors： Jin D,Harada K,Ohnishi S,Yamahara K,Kangawa K,Nagaya N

更新日期：2008-12-01 00:00:00

abstract：AIMS:Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of vascular homeostasis leading to reduced relaxation, hypertrophy, and a high...

journal_title：Cardiovascular research

authors： Wenzel P,Schuhmacher S,Kienhöfer J,Müller J,Hortmann M,Oelze M,Schulz E,Treiber N,Kawamoto T,Scharffetter-Kochanek K,Münzel T,Bürkle A,Bachschmid MM,Daiber A

更新日期：2008-11-01 00:00:00

abstract：AIMS:Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but...

journal_title：Cardiovascular research

authors： Frias MA,Somers S,Gerber-Wicht C,Opie LH,Lecour S,Lang U

更新日期：2008-10-01 00:00:00

abstract：AIMS:Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm ...

journal_title：Cardiovascular research

authors： Hu K,Scheer FA,Buijs RM,Shea SA

更新日期：2008-10-01 00:00:00

abstract：AIMS:Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma isoforms and their downstream effector pathways in mediating endothe...

journal_title：Cardiovascular research

authors： Heller R,Chang Q,Ehrlich G,Hsieh SN,Schoenwaelder SM,Kuhlencordt PJ,Preissner KT,Hirsch E,Wetzker R

更新日期：2008-10-01 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：AIMS:Our aim was to determine whether the repeated, binge administration of 3,4-methylenedioxymethamphetamine (ecstasy; MDMA) produces structural and/or functional changes in the myocardium that are associated with oxidative stress. METHODS AND RESULTS:Echocardiography and pressure-volume conductance catheters were us...

journal_title：Cardiovascular research

authors： Shenouda SK,Lord KC,McIlwain E,Lucchesi PA,Varner KJ

更新日期：2008-09-01 00:00:00

abstract：AIMS:ATP sensitive K(+) channels (K(ATP)) sense adenine nucleotide concentrations and thus couple the metabolic state of the cell to membrane potential. The hetero-octameric complex of a sulphonylurea receptor (SUR2B) and an inwardly rectifying K(+) channel (Kir6.1) and the corresponding native channel in smooth muscle...

journal_title：Cardiovascular research

authors： Farzaneh T,Tinker A

更新日期：2008-09-01 00:00:00

abstract：AIMS:KCNQ1 (alias KvLQT1 or Kv7.1) and KCNE1 (alias IsK or minK) co-assemble to form the voltage-activated K(+) channel responsible for I(Ks)-a major repolarizing current in the human heart-and their dysfunction promotes cardiac arrhythmias. The channel is a component of larger macromolecular complexes containing known...

journal_title：Cardiovascular research

authors： Nicolas CS,Park KH,El Harchi A,Camonis J,Kass RS,Escande D,Mérot J,Loussouarn G,Le Bouffant F,Baró I

更新日期：2008-08-01 00:00:00

abstract：AIMS:Vascular inflammation is a major atherogenic factor and Toll-like receptor (TLR) 2 ligands, including bacterial and serum lipoproteins, seem to be involved in atherogenesis. On this basis, we analysed the effect of lipoproteins and different lipid components on TLR2-dependent signalling. METHODS AND RESULTS:In TL...

journal_title：Cardiovascular research

authors： Dueñas AI,Aceves M,Fernández-Pisonero I,Gómez C,Orduña A,Crespo MS,García-Rodríguez C

更新日期：2008-08-01 00:00:00

abstract：:The heart is challenged by a plethora of extracellular stimuli over the course of a normal day, each of which distinctly influences myocardial contractile function. It is therefore not surprising that myocardial metabolism also oscillates in a time-of-day dependent manner. What is becoming increasingly apparent is tha...

journal_title：Cardiovascular research

authors： Bray MS,Young ME

更新日期：2008-07-15 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：AIMS:Alteration of connexin43 (Cx43)-mediated intercellular communication is known to promote susceptibility to ventricular tachyarrhythmias. However, the precise mechanism of the altered Cx43 responsible for arrhythmogenesis remains unclear. We sought to understand changes in impulse propagation of ventricular myocyte...

journal_title：Cardiovascular research

authors： Nakagami T,Tanaka H,Dai P,Lin SF,Tanabe T,Mani H,Fujiwara K,Matsubara H,Takamatsu T

更新日期：2008-07-01 00:00:00

abstract：AIMS:In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase Cepsilon, was shown to modulate the activity of N-ty...

journal_title：Cardiovascular research

authors： Maturana AD,Wälchli S,Iwata M,Ryser S,Van Lint J,Hoshijima M,Schlegel W,Ikeda Y,Tanizawa K,Kuroda S

更新日期：2008-06-01 00:00:00

abstract：AIMS:Hypertension is a risk factor for atherothrombotic vascular events. Angiotensin II (Ang II), one of the main vasoactive hormones of the renin-angiotensin system, has been associated with the development and progression of atherosclerosis. However, it is not fully known how Ang II contributes to lipid-enriched athe...

journal_title：Cardiovascular research

authors： Sendra J,Llorente-Cortés V,Costales P,Huesca-Gómez C,Badimon L

更新日期：2008-06-01 00:00:00

abstract：:Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response. The chemokin...

journal_title：Cardiovascular research

authors： Balestrieri ML,Balestrieri A,Mancini FP,Napoli C

更新日期：2008-05-01 00:00:00

abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...

journal_title：Cardiovascular research

authors： Tongers J,Knapp JM,Korf M,Kempf T,Limbourg A,Limbourg FP,Li Z,Fraccarollo D,Bauersachs J,Han X,Drexler H,Fiedler B,Wollert KC

更新日期：2008-05-01 00:00:00

abstract：:Sprouting angiogenesis is an invasive process that involves proteolytic activities required for the degradation of the endothelial basement membrane, cell migration with removal of obstructing matrix proteins, and generation of space in the matrix to allow endothelial cells to form a proper lumen. In the last decade i...

journal_title：Cardiovascular research

authors： van Hinsbergh VW,Koolwijk P

更新日期：2008-05-01 00:00:00

abstract：AIMS:The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration, proliferation, and capillary-like tube formation in vitro. It is unknown whether S1P stimulates in vivo angiogenesis induced under tissue ischaemia. We investigated the effects of both exogenously...

journal_title：Cardiovascular research

authors： Oyama O,Sugimoto N,Qi X,Takuwa N,Mizugishi K,Koizumi J,Takuwa Y

更新日期：2008-05-01 00:00:00

abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

journal_title：Cardiovascular research

authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

更新日期：2008-05-01 00:00:00

abstract：AIMS:Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify eviden...

journal_title：Cardiovascular research

authors： Benest AV,Harper SJ,Herttuala SY,Alitalo K,Bates DO

更新日期：2008-05-01 00:00:00

abstract：AIMS:Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages. METHODS AND RESULTS:Gene expression profile was s...

journal_title：Cardiovascular research

authors： Tuomisto TT,Lumivuori H,Kansanen E,Häkkinen SK,Turunen MP,van Thienen JV,Horrevoets AJ,Levonen AL,Ylä-Herttuala S

更新日期：2008-04-01 00:00:00

abstract：AIMS:Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. W...

journal_title：Cardiovascular research

authors： Knuefermann P,Schwederski M,Velten M,Krings P,Ehrentraut H,Rüdiger M,Boehm O,Fink K,Dreiner U,Grohé C,Hoeft A,Baumgarten G,Koch A,Zacharowski K,Meyer R

更新日期：2008-04-01 00:00:00

abstract：:Mechanical stress signals transmitted through the heart walls during hemodynamic loading are sensed by the myocytes, which respond with changes in contractile performance and gene expression. External forces play an important role in physiological heart development and hypertrophy, but disruption of the well-balanced ...

journal_title：Cardiovascular research

authors： Linke WA

更新日期：2008-03-01 00:00:00

abstract：AIMS:Cholesteryl ester transfer protein (CETP) has a well-established role in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear. METHODS AND RESULTS:Neither overexpression of CETP nor treatment with CETP inhibitor Torcetrapib ...

journal_title：Cardiovascular research

authors： Tchoua U,D'Souza W,Mukhamedova N,Blum D,Niesor E,Mizrahi J,Maugeais C,Sviridov D

更新日期：2008-03-01 00:00:00

abstract：AIM:Clinical use of amiodarone is associated with occasional development of torsade de pointes (TdP). However, preclinical models have failed to demonstrate the proarrhythmic potential of amiodarone. The objective of this study was to reveal and explain the pro- and anti-arrhythmic effects of acute exposure to amiodaro...

journal_title：Cardiovascular research

authors： Wu L,Rajamani S,Shryock JC,Li H,Ruskin J,Antzelevitch C,Belardinelli L

更新日期：2008-02-01 00:00:00

abstract：AIMS:This study examines the effect of endogenous male sex hormones on thromboxane A2 (TXA2), prostaglandin (PG) I2, PGF(2 alpha), and PGE I2 release, as well as their role in acetylcholine (ACh)-mediated relaxation in the aorta. METHODS AND RESULTS:Aortic segments from orchidectomized and control male Sprague-Dawley ...

journal_title：Cardiovascular research

authors： Martorell A,Blanco-Rivero J,Aras-López R,Sagredo A,Balfagón G,Ferrer M

更新日期：2008-02-01 00:00:00